BDBM50453816 BGB-283::Bgb 283::Lifirafenib

SMILES c1cc2c(cc1C(F)(F)F)nc([nH]2)[C@H]3[C@H]4[C@@H]3Oc5c4cc(cc5)Oc6ccnc7c6CCC(=O)N7

InChI Key InChIKey=NGFFVZQXSRKHBM-UHFFFAOYSA-N

Data  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50453816   

TargetSerine/threonine-protein kinase B-raf(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50453816(BGB-283 | Bgb 283 | Lifirafenib)
Affinity DataIC50: 23nMAssay Description:Inhibition of BRAF (unknown origin) using MEK1 K97R mutant as substrate preincubated for 60 to 120 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)