BDBM50452100 CHEMBL4216497

SMILES CN(C)/N=C\1/CN(C(=O)[C@@H](CN1)Cc2cc(ccc2OC)Cl)CC(=O)Nc3cccc(c3)S(=O)(=O)C

InChI Key InChIKey=NWZUZBYLXNQLIF-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50452100   

TargetKallikrein-7(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452100(CHEMBL4216497)
Affinity DataIC50: 820nMAssay Description:Inhibition of thermolysin activated recombinant human C-terminal 10-His tagged KLK7 preincubated for 10 mins followed by MOCAc-Arg-Pro-Lys-Pro-Val-Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKallikrein-5(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452100(CHEMBL4216497)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged KLK5 preincubated for 10 mins followed by Boc-Val-Pro-Arg-MCA peptide substrate addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTrypsin(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452100(CHEMBL4216497)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human trypsin preincubated for 10 mins followed by Boc-Gln-Ala-Arg-MCA peptide substrate addition measured after 30 mins by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetKallikrein-7(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452100(CHEMBL4216497)
Affinity DataIC50: 820nMAssay Description:Inhibition of recombinant human KLK7 using MOCAc-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate preincubated for 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)