BDBM50446431 CHEMBL3109933

SMILES CN(C)C(=O)c1ccc(Nc2cc3n(C(=O)OC(C)(C)C)c(cc3cn2)-c2cnn(C)c2)c(Cl)c1

InChI Key InChIKey=KYBALIQJYSWGLI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50446431   

TargetAurora kinase A(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50446431(CHEMBL3109933)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of N-terminal His-tagged Aurora A (unknown origin) using 5FAM-LRRASLG-CONH2 as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50446431(CHEMBL3109933)
Affinity DataIC50: 600nMAssay Description:Inhibition of Myc-tagged wild type MPS1 autophosphorylation in human HCT116 cells after 2 hrs in presence of proteosome inhibitor MG132More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50446431(CHEMBL3109933)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50446431(CHEMBL3109933)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of NEK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50446431(CHEMBL3109933)
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal 6XHis-tagged/GST-tagged full length human MPS1 expressed in recombinant baculovirus infected sf9 insect cells using 5FAM-DHT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50446431(CHEMBL3109933)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of full length CDK2/Cyclin A (unknown origin) using 5FAMQSPKKG-CONH2 as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed