BDBM50443085 AFQ056::Mavoglurant

SMILES Cc1cccc(c1)C#C[C@@]2(CCC[C@@H]3[C@H]2CCN3C(=O)OC)O

InChI Key InChIKey=ZFPZEYHRWGMJCV-UHFFFAOYSA-N

Data  2 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50443085   

TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50443085(Mavoglurant | AFQ056)
Affinity DataIC50: 10nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50443085(Mavoglurant | AFQ056)
Affinity DataIC50: 72nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50443085(Mavoglurant | AFQ056)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 StaR domain (569 to 836 residues) (unknown origin) expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Human)
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50443085(Mavoglurant | AFQ056)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)