BDBM50439277 CHEMBL2419490

SMILES CCOC(=O)c1cc(c(nc1C)N2CCC(CC2)C(=O)NS(=O)(=O)Cc3ccccc3)C#N

InChI Key InChIKey=NEMHKCNXXRQYRF-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50439277   

TargetCytochrome P450 2C9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50439277(CHEMBL2419490)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human recombinant CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50439277(CHEMBL2419490)
Affinity DataIC50: 3.20E+3nMAssay Description:Antagonist activity at P2Y12 receptor in human whole blood assessed as inhibition of ADP-induced platelet aggregation after 5 mins by residual platel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 12(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50439277(CHEMBL2419490)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at P2Y12 receptor (unknown origin) expressed in CHO cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 12(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50439277(CHEMBL2419490)
Affinity DataIC50: 11nMAssay Description:Displacement of [125I]-AZ11931285 from P2Y12 receptor (unknown origin) expressed in CHO cell membrane after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 12(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50439277(CHEMBL2419490)
Affinity DataIC50: 9nMAssay Description:Displacement of [125I]AZ11931285 from human P2Y12 receptor expressed in CHOK1 cell membrane after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 12(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50439277(CHEMBL2419490)
Affinity DataIC50: 14nMAssay Description:Displacement of [125I]AZ11931285 from human P2Y12 receptor expressed in CHOK1 cell membrane after 60 secondsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 12(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50439277(CHEMBL2419490)
Affinity DataIC50: 22nMAssay Description:Displacement of [125I]AZ11931285 from human P2Y12 receptor expressed in CHOK1 cell membrane after 30 secondsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 12(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50439277(CHEMBL2419490)
Affinity DataIC50: 44nMAssay Description:Displacement of [125I]AZ11931285 from human P2Y12 receptor expressed in CHOK1 cell membrane after 10 secondsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 12(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50439277(CHEMBL2419490)
Affinity DataIC50: 9nMAssay Description:Antagonist activity P2Y12 receptor in human washed platelets assessed as inhibition of ADP-induced platelet aggregation after 5 to 90 mins by spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 12(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50439277(CHEMBL2419490)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at P2Y12 receptor (unknown origin) assessed as inhibition of ADP-induced [35S]GTPgammaS binding after 45 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 12(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50439277(CHEMBL2419490)
Affinity DataIC50: 3.20E+3nMAssay Description:Antagonist activity P2Y12 receptor in human blood assessed as inhibition of ADP-induced platelet aggregation measured as residual platelet count afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 12(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50439277(CHEMBL2419490)
Affinity DataIC50: 3.60E+3nMAssay Description:Antagonist activity at P2Y12 receptor in human platelet rich plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)