BDBM50439154 CHEMBL2418761

SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3cnn(Cc4cc(F)ccc4F)c3)c2c1

InChI Key InChIKey=SDWMCZUOCJDBOJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50439154   

TargetALK tyrosine kinase receptor(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50439154(CHEMBL2418761)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of ALK in human KARPAS299 cells assessed as phosphorylated Stat3 level after 6 hrs by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50439154(CHEMBL2418761)
Affinity DataIC50: 900nMAssay Description:Inhibition of ALK in human KARPAS299 cells assessed as phosphorylated ALK level after 6 hrs by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50439154(CHEMBL2418761)
Affinity DataIC50: 29nMAssay Description:Inhibition of wild type human recombinant ALK after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50439154(CHEMBL2418761)
Affinity DataIC50: 29nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed