BDBM50435735 CHEMBL2392553

SMILES CN1CCC(CC1)NC(=O)c2ccc(c(c2)OC)Nc3ncc4c(n3)N(CC(C(=O)N4C)(F)F)C5CCCC5

InChI Key InChIKey=DJNZZLZKAXGMMC-UHFFFAOYSA-N

Data  1 IC50  6 Kd

PDB links: 6 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50435735   

TargetSerine/threonine-protein kinase PLK1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50435735(CHEMBL2392553)
Affinity DataIC50: 4nMAssay Description:Inhibition of PLK1 (unknown origin) using biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50435735(CHEMBL2392553)
Affinity DataKd:  260nMAssay Description:Binding affinity to recombinant human N-terminal hexaHis-tagged BRD4 expressed in Escherichia coli BL21 (DE3) cells by MST assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50435735(CHEMBL2392553)
Affinity DataKd:  120nMAssay Description:Binding affinity to recombinant human N-terminal hexaHis-tagged BRD4 expressed in Escherichia coli BL21 (DE3) cells by qPCR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50435735(CHEMBL2392553)
Affinity DataKd:  267nMAssay Description:Binding affinity to recombinant human N-terminal hexaHis-tagged BRD4 expressed in Escherichia coli BL21 (DE3) cells by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain testis-specific protein(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50435735(CHEMBL2392553)
Affinity DataKd:  1.90E+3nMAssay Description:Binding affinity to recombinant human N-terminal hexaHis-tagged BRDT expressed in Escherichia coli BL21 (DE3) cells by MST assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain testis-specific protein(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50435735(CHEMBL2392553)
Affinity DataKd:  390nMAssay Description:Binding affinity to recombinant human N-terminal hexaHis-tagged BRDT expressed in Escherichia coli BL21 (DE3) cells by qPCR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain testis-specific protein(Human)
Moffitt Cancer Center

Curated by ChEMBL
LigandPNGBDBM50435735(CHEMBL2392553)
Affinity DataKd:  1.80E+3nMAssay Description:Binding affinity to recombinant human N-terminal hexaHis-tagged BRDT expressed in Escherichia coli BL21 (DE3) cells by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)