BDBM50434157 CHEMBL2381958::US9340549, 78

SMILES CC1([C@@H](N(C(=O)O1)c2ccc(cc2)C(=O)Nc3cccc4c3nccc4)c5ccccc5)C

InChI Key InChIKey=LUYWAGVRXKSNLL-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50434157   

LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50: 198nMT: 2°CAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50: 189nMT: 2°CAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PARP6 (unknown origin) using histone as substrate after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PARP3 (unknown origin) using histone as substrate after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PARP2 (unknown origin) using histone as substrate after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PARP1 (unknown origin) using histone as substrate after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50434157(CHEMBL2381958 | US9340549, 78)
Affinity DataIC50: 200nMAssay Description:Inhibition of human TNKS1 (1030 to 1317 residues) measured after 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)