BDBM50433629 CHEMBL2380845

SMILES c1ccc(cc1)C(=O)Nc2ccc(cc2)Nc3ccnc4c3-c5ccccc5C(=O)N4

InChI Key InChIKey=XLSPYLMTRXPYKY-UHFFFAOYSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50433629   

TargetHigh affinity nerve growth factor receptor(Human)
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50: 819nMAssay Description:Inhibition of TrkA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase WNK3(Human)
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50: 401nMAssay Description:Inhibition of WNK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50: 211nMAssay Description:Inhibition of SIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50: 149nMAssay Description:Inhibition of ACK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50: 41nMAssay Description:Inhibition of CHK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50: 36nMAssay Description:Inhibition of LIMK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50: 15nMAssay Description:Inhibition of Ret (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50: 208nMAssay Description:Inhibition of aurora-B in human MIAPaCa2 cells assessed as reduction of phosphorylation of histone H3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50: 4nMAssay Description:Inhibition of aurora-A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase B(Human)
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50433629(CHEMBL2380845)
Affinity DataIC50: 1nMAssay Description:Inhibition of aurora-B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed