BDBM50431893 ARRY-520::CHEMBL2347655

SMILES CN(C(=O)N1[C@](SC(=N1)c2cc(ccc2F)F)(CCCN)c3ccccc3)OC

InChI Key InChIKey=LLXISKGBWFTGEI-UHFFFAOYSA-N

Data  4 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50431893   

TargetKinesin-like protein KIF11(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50431893(ARRY-520 | CHEMBL2347655)
Affinity DataIC50: 18nMAssay Description:Inhibition of His-tagged KSP motor domain (1 to 369) (unknown origin) assessed as inhibition of microtubule-stimulated KSP ATPase activity preincuabt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50431893(ARRY-520 | CHEMBL2347655)
Affinity DataIC50: 6nMAssay Description:Inhibition of Eg5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50431893(ARRY-520 | CHEMBL2347655)
Affinity DataIC50: 6nMAssay Description:Inhibition EG5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKinesin-like protein KIF11(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50431893(ARRY-520 | CHEMBL2347655)
Affinity DataIC50: 6nMAssay Description:Inhibition of microtubule-stimulated Eg5 ATPase activity in human HL-60 cells after 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)