BDBM50431381 FOSTAMATINIB::R-788 Free acid::R-935788 Free acid

SMILES CC1(C(=O)N(c2c(ccc(n2)Nc3c(cnc(n3)Nc4cc(c(c(c4)OC)OC)OC)F)O1)COP(=O)(O)O)C

InChI Key InChIKey=GKDRMWXFWHEQQT-UHFFFAOYSA-N

Data  1 KI  9 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50431381   

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431381(R-788 Free acid | R-935788 Free acid | FOSTAMATINI...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant truncated SYK (360 to 365 amino acid residues) using N-terminally biotinylated EPEGDYEEVLE peptide as substrate asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431381(R-788 Free acid | R-935788 Free acid | FOSTAMATINI...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431381(R-788 Free acid | R-935788 Free acid | FOSTAMATINI...)
Affinity DataIC50: 267nMAssay Description:Inhibition of SYK in human Ramos cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431381(R-788 Free acid | R-935788 Free acid | FOSTAMATINI...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of SYK in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431381(R-788 Free acid | R-935788 Free acid | FOSTAMATINI...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Federal University of Parana

Curated by ChEMBL
LigandPNGBDBM50431381(R-788 Free acid | R-935788 Free acid | FOSTAMATINI...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human ABCG2 expressing membrane vesicles assessed inhibition of BCRP- mediated transport of [3H]estrone 3-sulfate for 2 mins using [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431381(R-788 Free acid | R-935788 Free acid | FOSTAMATINI...)
Affinity DataIC50: 41nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431381(R-788 Free acid | R-935788 Free acid | FOSTAMATINI...)
Affinity DataIC50: 17nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain testis-specific protein(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50431381(R-788 Free acid | R-935788 Free acid | FOSTAMATINI...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human recombinant BRDTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431381(R-788 Free acid | R-935788 Free acid | FOSTAMATINI...)
Affinity DataKi:  30nMAssay Description:Binding affinity to SYK (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed