BDBM50429759 CHEMBL2336358::N-O-Tolylcinnamamide

SMILES Cc1ccccc1NC(=O)\C=C\c1ccccc1

InChI Key InChIKey=VHCQQXKZAMLIPM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50429759   

Target72 kDa type IV collagenase(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429759(N-O-Tolylcinnamamide | CHEMBL2336358)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human recombinant MMP2 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429759(N-O-Tolylcinnamamide | CHEMBL2336358)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human recombinant MMP9 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429759(N-O-Tolylcinnamamide | CHEMBL2336358)
Affinity DataIC50: 4.52E+3nMAssay Description:Inhibition of human recombinant MMP1 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50429759(N-O-Tolylcinnamamide | CHEMBL2336358)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of autophosphorylation of His6-tagged EGFR cytoplasmic domain (unknown origin) expressed in Sf9 cells by DELFIA time resolved fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article