BDBM50427453 CHEMBL2322228::US10308662, Compound 28::US9505780, 28

SMILES O=c1cc(oc2c(csc12)-c1ccc2OCCOc2c1)N1CCOCC1

InChI Key InChIKey=BYTKNUOMWLJVNQ-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50427453   

LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 214nMAssay Description:Inhibition of PI3K p110beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 9nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 280nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 158nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 34nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 158nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 960nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 214nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 34nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-167](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 241nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 241nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 960nMAssay Description:Inhibition of PI3K p110delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 34nMAssay Description:Inhibition of PI3K p110alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of PI3K p110gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 289nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 43nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 158nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 960nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 214nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 34nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427453(CHEMBL2322228 | US9505780, 28 | US10308662, Compou...)
Affinity DataIC50: 1.55E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent