BDBM50426176 CHEMBL2316958

SMILES CC(=CC(=O)CCC(=O)N1CCN(CC1)Cc2cc3c(s2)c(nc(n3)c4cccc5c4cn[nH]5)N6CCOCC6)C

InChI Key InChIKey=DLNUPKDFXMWRFP-UHFFFAOYSA-N

Data  11 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50426176   

LigandPNGBDBM50426176(CHEMBL2316958)
Affinity DataEC50:  10nMAssay Description:Inhibition of PI3Kalpha in human SKOV3 cells assessed as inhibition of Akt Ser473 phosphorylation at 1 to 1000 nM after 1 hr by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine kinase 2(Human)
Celgene Avilomics Research

Curated by ChEMBL
LigandPNGBDBM50426176(CHEMBL2316958)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of SPHK2 (unknown origin) by ADP-GLO assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Celgene Avilomics Research

Curated by ChEMBL
LigandPNGBDBM50426176(CHEMBL2316958)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of SPHK1 (unknown origin) by ADP-GLO assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Celgene Avilomics Research

Curated by ChEMBL
LigandPNGBDBM50426176(CHEMBL2316958)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PI4Kbeta (unknown origin) by ADP-GLO assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Celgene Avilomics Research

Curated by ChEMBL
LigandPNGBDBM50426176(CHEMBL2316958)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PI4Kalpha (unknown origin) by ADP-GLO assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Celgene Avilomics Research

Curated by ChEMBL
LigandPNGBDBM50426176(CHEMBL2316958)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PI3KC3 (unknown origin) by ADP-GLO assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50426176(CHEMBL2316958)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PI3KC2A (unknown origin) by ADP-GLO assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50426176(CHEMBL2316958)
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50426176(CHEMBL2316958)
Affinity DataIC50: 240nMAssay Description:Inhibition of PI3Kgamma (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50426176(CHEMBL2316958)
Affinity DataIC50: 166nMAssay Description:Inhibition of PI3Kbeta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50426176(CHEMBL2316958)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of PI3Kalpha in human SKOV3 cells assessed as inhibition of Akt Ser473 phosphorylation at 1 to 1000 nM after 1 hr by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50426176(CHEMBL2316958)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of PI3Kalpha H1047R mutant in human SK-OV-3 cells assessed as protein phosphorylation incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)