BDBM50425687 CHEMBL2315565

SMILES CNC(=O)c1ccccc1Nc1c(C(F)(F)F)cnc2[nH]c(-c3ccc(N4CCOCC4)cc3)cc12

InChI Key InChIKey=VHPUVIGQSMCXKT-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50425687   

TargetFocal adhesion kinase 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425687BDBM50425687(CHEMBL2315565)
Affinity DataKd:  35nMAssay Description:Binding affinity to FAK (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425687BDBM50425687(CHEMBL2315565)
Affinity DataIC50: 45nMAssay Description:Inhibition of FAK (unknown origin) using biotinylated His-TEV-hsFAK(31-686)(K454R) substrate after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50425687BDBM50425687(CHEMBL2315565)
Affinity DataIC50: 83nMAssay Description:Inhibition of FAK in human HT-29 cells assessed as phosphorylation at tyrosine 397 after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed