BDBM50425360 CHEMBL2316207

SMILES c1ccc(cc1)C(=O)Nc2cc(ccc2F)Nc3ccc4c(c3)CCc5ccc(cc5C4=O)C(=O)NCCN6CCOCC6

InChI Key InChIKey=JWZSSEWMVYKYKW-UHFFFAOYSA-N

Data  7 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50425360   

TargetMitogen-activated protein kinase 14(Human)
University of T£Bingen

Curated by ChEMBL
LigandPNGBDBM50425360(CHEMBL2316207)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of p38alpha MAP kinase (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of T£Bingen

Curated by ChEMBL
LigandPNGBDBM50425360(CHEMBL2316207)
Affinity DataIC50: 31nMAssay Description:Inhibition of p38alpha MAP kinase in whole blood (unknown origin) assessed as lipopolysaccharide-stimulated TNF-alpha release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of T£Bingen

Curated by ChEMBL
LigandPNGBDBM50425360(CHEMBL2316207)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of T£Bingen

Curated by ChEMBL
LigandPNGBDBM50425360(CHEMBL2316207)
Affinity DataKd:  3.90nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells assessed as dissociation rate consta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of T£Bingen

Curated by ChEMBL
LigandPNGBDBM50425360(CHEMBL2316207)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of T£Bingen

Curated by ChEMBL
LigandPNGBDBM50425360(CHEMBL2316207)
Affinity DataIC50: 38nMAssay Description:Inhibition of P38 alpha MAPK in human whole blood assessed as reduction in TNF-alpha release after 10 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of T£Bingen

Curated by ChEMBL
LigandPNGBDBM50425360(CHEMBL2316207)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged p38alpha MAPK expressed in baculovirus infected Sf9 insect cells using p38 peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of T£Bingen

Curated by ChEMBL
LigandPNGBDBM50425360(CHEMBL2316207)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of NanoBRET kinase tracer K4 binding to full-length human C-terminal NanoLuc-tagged p38alpha MAPK expressed in HEK293T cells incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of T£Bingen

Curated by ChEMBL
LigandPNGBDBM50425360(CHEMBL2316207)
Affinity DataIC50: 38nMAssay Description:Inhibition of p38alpha MAPK in human whole blood assessed as reduction in LPS-induced TNFalpha production preincubated for 2.5 hrs followed by LPS st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)