BDBM50424727 CHEMBL2314173::US10093640, Example 2::US10844032, Example 2

SMILES Cc1cc(cc(c1Cl)C)OCCCc2c3ccccc3sc2C(=O)O

InChI Key InChIKey=GFWMYYSJLSUPMD-UHFFFAOYSA-N

Data  7 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50424727   

LigandPNGBDBM50424727(CHEMBL2314173 | US10093640, Example 2 | US10844032...)
Affinity DataIC50: 400nMpH: 7.5 T: 2°CAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50424727(CHEMBL2314173 | US10093640, Example 2 | US10844032...)
Affinity DataIC50: 320nMpH: 7.5 T: 2°CAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetBcl2-associated agonist of cell death(Human)
Novartis

US Patent
LigandPNGBDBM50424727(CHEMBL2314173 | US10093640, Example 2 | US10844032...)
Affinity DataIC50: 1.90E+3nMpH: 7.5 T: 2°CAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Novartis

US Patent
LigandPNGBDBM50424727(CHEMBL2314173 | US10093640, Example 2 | US10844032...)
Affinity DataIC50: 4.10E+4nMpH: 7.5 T: 2°CAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

LigandPNGBDBM50424727(CHEMBL2314173 | US10093640, Example 2 | US10844032...)
Affinity DataKi:  320nMAssay Description:Displacement of FITC-AHx-KALETLRRVGDGVQRNHETAF-NH2 from human MCl1 (172 to 327) expressed in Escherichia coli BL21 (DE3) after 1 hr by fluorescence p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50424727(CHEMBL2314173 | US10093640, Example 2 | US10844032...)
Affinity DataKi:  320nMAssay Description:The assay was run using a fluorescein isothiocyanate-labeled BH3 peptide derived from Bak (FITC-AHx-GQVGRQLAIIGDDINR-NH2) that was purchased from Gen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50424727(CHEMBL2314173 | US10093640, Example 2 | US10844032...)
Affinity DataKi:  400nMAssay Description:The assay was run using a fluorescein isothiocyanate-labeled BH3 peptide derived from Bak (FITC-AHx-GQVGRQLAIIGDDINR-NH2) that was purchased from Gen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetApoptosis regulator Bcl-2(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50424727(CHEMBL2314173 | US10093640, Example 2 | US10844032...)
Affinity DataKi:  1.90E+3nMAssay Description:The assay was run using a fluorescein isothiocyanate-labeled BH3 peptide derived from Bak (FITC-AHx-GQVGRQLAIIGDDINR-NH2) that was purchased from Gen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50424727(CHEMBL2314173 | US10093640, Example 2 | US10844032...)
Affinity DataKi:  5.30E+3nMAssay Description:Displacement of FITC-AHx-GQVGRQLAIIGDDINR-NH2 from Bcl2 (unknown origin) after 1 hr by fluorescence polarization anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Novartis

US Patent
LigandPNGBDBM50424727(CHEMBL2314173 | US10093640, Example 2 | US10844032...)
Affinity DataKi: >1.50E+4nMAssay Description:Displacement of FITC-AHx-GQVGRQLAIIGDDINR-NH2 from Bcl-xL (unknown origin) after 1 hr by fluorescence polarization anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) -44,87-209](Human)
Vanderbilt University

US Patent
LigandPNGBDBM50424727(CHEMBL2314173 | US10093640, Example 2 | US10844032...)
Affinity DataKi:  4.10E+4nMAssay Description:The assay was run using a fluorescein isothiocyanate-labeled BH3 peptide derived from Bak (FITC-AHx-GQVGRQLAIIGDDINR-NH2) that was purchased from Gen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent