BDBM50422780 CHEMBL5286061

SMILES Cn1ccc2c1cc(cc2)c3cc(cc4c3nccn4)Nc5cnccc5C(=O)NC6CCOCC6

InChI Key InChIKey=PNSFFJLFHRNWQC-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50422780   

Target6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Human)
Liaocheng University

Curated by ChEMBL
LigandPNGBDBM50422780(CHEMBL5286061)
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of PFKFB3 in human HCT-116 cells assessed as inhibition of glucose induced lactate production by absorbance based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
Target6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Human)
Liaocheng University

Curated by ChEMBL
LigandPNGBDBM50422780(CHEMBL5286061)
Affinity DataIC50: 47nMAssay Description:Inhibition of human recombinant His-tagged PFKFB3 expressed in Escherichia coli using Fructose-6-phosphate incubated for 2 hrs in presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)