BDBM50413752 CHEMBL2012519::L-783277

SMILES COc1cc(O)c2c(CCCC(=O)C(=O)C(O)CCC[C@H](C)OC2=O)c1

InChI Key InChIKey=CZVAYVPOBIDGLC-UHFFFAOYSA-N

Data  47 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 47 hits for monomerid = 50413752   

TargetTyrosine-protein kinase Lck(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 750nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2A by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKAalpha by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 303nMAssay Description:Inhibition of cKIT by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3-beta by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDK1 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR3 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 57nMAssay Description:Inhibition of VEGFR2 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant FLT3 ITD mutant (unknown origin) by RBC kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 62nMAssay Description:Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant FLT3 D835Y mutant (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38alpha by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 125nMAssay Description:Inhibition of human ALK1 using casein as substrate in presence of [gamma-33P]-ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human FLT4 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human MEK2 using ERK2 as substrate in presence of [gamma-33P]-ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK peptide as substrate in presence of [gamma-33P]-ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human KDR using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 388nMAssay Description:Inhibition of human MKK6 using p38a as substrate in presence of [gamma-33P]-ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK substrate and [gamma-33P]-ATP by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human VEGFR2 using poly[Glu:Tyr] (4:1) substrate and [gamma-33P]-ATP by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Korea University

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of human VEGFR3 using poly[Glu:Tyr] (4:1) substrate and [gamma-33P]-ATP by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 325nMAssay Description:Inhibition of GST-tagged MNK1 (unknown origin) expressed in Escherichia coli BL21(DE3) using 5-FAM-TATKSGSTTKNRFVV-NH 2 peptide as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 60nMAssay Description:Inhibition of GST-tagged MNK2 (unknown origin) expressed in Escherichia coli BL21(DE3) using 5-FAM-TATKSGSTTKNRFVV-NH 2 peptide as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1R by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of LCK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 640nMAssay Description:Inhibition of MK5 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RET by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of TYK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 950nMAssay Description:Inhibition of ERK2 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetAurora kinase A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora A kinase by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Axl by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ZAP70 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetEphrin type-A receptor 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EPHA4 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HGFR by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EPHB4 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK1 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKN1 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKN2 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ROCK2 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 763nMAssay Description:Inhibition of ALK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetInsulin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of INSR by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 15nMAssay Description:Inhibition of MEK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed