BDBM50405637 CHEMBL5273641

SMILES Nc1ncc(-c2nc(nc(n2)N2CCN(CC2)C(=O)CNC(=O)C2CCN(CC2)C(=O)C=C)N2CCOCC2)c(n1)C(F)F

InChI Key InChIKey=YAPSKJOBRAWBJI-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50405637   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Merck Healthcare

Curated by ChEMBL

LigandBDBM50405637(CHEMBL5273641)Copy SMILESCopy InChI

Affinity DataIC50: 82nMAssay Description:Inhibition of PI3Kalpha (unknown origin) in human SK-OV-3 cellsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
12/17/2024
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Merck Healthcare

Curated by ChEMBL

LigandBDBM50405637(CHEMBL5273641)Copy SMILESCopy InChI

Affinity DataIC50: 2.90nMAssay Description:Inhibition of N-His-tagged recombinant PI3Kalpha (unknown origin) using Alexa Fluor-Kinase Tracer 315 by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/18/2024
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL