BDBM50403060 CHEMBL2216830

SMILES CCN(CC)CCCCNc1ncc2c(n1)N(C(=O)N(C2)c3c(c(cc(c3Cl)OC)OC)Cl)Cc4cccc(c4)NC(=O)C=C

InChI Key InChIKey=DNVFTXQYIYFQBW-UHFFFAOYSA-N

Data  16 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50403060   

TargetFibroblast growth factor receptor 4(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 261nMAssay Description:Inhibition of human recombinant His-tagged FGFR4 cytoplasmic domain (781 to 1338 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 189nMAssay Description:Inhibition of recombinant FGFR4 (unknown origin) incubated for 1 hr in presence of ATP by Z-LYTE enzymatic kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant FGFR3 (unknown origin) incubated for 1 hr in presence of ATP by Z-LYTE enzymatic kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of recombinant FGFR2 (unknown origin) incubated for 1 hr in presence of ATP by Z-LYTE enzymatic kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) incubated for 1 hr in presence of ATP by Z-LYTE enzymatic kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataEC50:  14nMAssay Description:Inhibition of Tel-fused FGFR1 (unknown origin) expressed in mouse Ba/F3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant His-tagged FGFR3 cytoplasmic domain (399 to 806 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2020
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 189nMAssay Description:Inhibition of FGFR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Guangzhou Institutes of Biomedicine and Health

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 261nMAssay Description:Inhibition of His-tagged cytoplasmic recombinant human FGFR4 (781 to 1338 residues) expressed in baculovirus expression system using Tyr 4 peptide as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of His-tagged cytoplasmic recombinant human FGFR1 (308 to 731 residues) expressed in baculovirus expression system using Tyr 4 peptide as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 6nMAssay Description:Inhibition of His-tagged cytoplasmic recombinant human FGFR3 (399 to 806 residues) expressed in baculovirus expression system using Tyr 4 peptide as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of His-tagged cytoplasmic recombinant human FGFR2 (403 to 822 residues) expressed in baculovirus expression system using Tyr 4 peptide as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of recombinant FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of FGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50403060(CHEMBL2216830)
Affinity DataIC50: 12nMAssay Description:Inhibition of FGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed