BDBM50397776 CHEMBL2177187::US9593129, Example 1

SMILES CC[C@@H](C(=O)OC(C)(C)C)N1[C@@H]([C@H](C[C@@H](C1=O)CC(=O)O)c2cccc(c2)Cl)c3ccc(cc3)Cl

InChI Key InChIKey=ZEMLYWMOSZRCQL-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50397776   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandPNGBDBM50397776(CHEMBL2177187 | US9593129, Example 1)
Affinity DataIC50: 40nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2019
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandPNGBDBM50397776(CHEMBL2177187 | US9593129, Example 1)
Affinity DataIC50: 4nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2019
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetCellular tumor antigen p53(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50397776(CHEMBL2177187 | US9593129, Example 1)
Affinity DataIC50: 4.30E+3nMAssay Description:Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed