BDBM50396534 CHEMBL2171124

SMILES Cn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(c2)C(F)(F)F)c2c(N)ncnc12

InChI Key InChIKey=SIXVRXARNAVBTC-UHFFFAOYSA-N

Data  32 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50396534   

TargetMyosin light chain kinase 2, skeletal/cardiac muscle(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 701nMAssay Description:Inhibition of MLCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 18nMAssay Description:Inhibition of GST tagged human recombinant RIPK1 incubated for 4 hrs by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human GST-tagged RIPK1 (1 to 479 residues) incubated for 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 890nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of GST-tagged PERK cytoplasmic domain (536 to 1116) (unknown origin) assessed as biotinylated His6-tagged EIF2alpha phosphorylation preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 420nMAssay Description:Inhibition of HRI assessed as EIF2AK1 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 696nMAssay Description:Inhibition of PKR assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 154nMAssay Description:Inhibition of c-KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 412nMAssay Description:Inhibition of BRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 10(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 452nMAssay Description:Inhibition of MLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 474nMAssay Description:Inhibition of c-MERMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 524nMAssay Description:Inhibition of DDR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 407nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of IKBKEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of TRKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of MLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of NEK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibition of MAP4K5More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of MLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 2.71E+3nMAssay Description:Inhibition of AXLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 2.96E+3nMAssay Description:Inhibition of TRKBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of YES1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase WNK2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 3.89E+3nMAssay Description:Inhibition of WNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 30nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396534(CHEMBL2171124)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed