BDBM50394684 CHEMBL2165615

SMILES Cc1cc2c(o1)cc(cc2Oc3cnc(nc3)C(=O)N(C)C)C(=O)Nc4cnc(cn4)C

InChI Key InChIKey=MASKQITXHVYVFL-UHFFFAOYSA-N

Data  5 EC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50394684   

TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394684(CHEMBL2165615)
Affinity DataEC50:  190nMAssay Description:Activation of human recombinant glucokinase by matrix assay in presence of glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394684(CHEMBL2165615)
Affinity DataEC50:  188nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHexokinase-4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394684(CHEMBL2165615)
Affinity DataEC50:  900nMAssay Description:Induction of glucokinase translocation from nucleus to cytoplasm in cryopreserved rat hepatocytes after 1 hr by Hoechst staining-based fluorescence m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394684(CHEMBL2165615)
Affinity DataEC50:  930nMAssay Description:Activation of recombinant human liver glucokinase 2 assessed as reduction in NADH production in presence of 5 mM glucose by G6PDH coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHexokinase-4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394684(CHEMBL2165615)
Affinity DataEC50:  1.09E+3nMAssay Description:Activation of recombinant human liver glucokinase 2 assessed as assessed as reduction in Km for glucose in presence of 5 mM glucose by G6PDH coupled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)