BDBM50393042 CHEMBL2152712

SMILES CC(C)(C)C(=O)NCc1ccc(c(c1)C(=O)Nc2[nH]ccn2)Cl

InChI Key InChIKey=MBAHGUNQNAJTLD-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50393042   

TargetProstaglandin E synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393042(CHEMBL2152712)
Affinity DataIC50: 240nMAssay Description:Inhibition of human mPGES-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393042(CHEMBL2152712)
Affinity DataIC50: 870nMAssay Description:Inhibition of human mPGES-1 assessed as production of PGE2 by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393042(CHEMBL2152712)
Affinity DataIC50: 740nMAssay Description:Inhibition of mPGES-1 in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393042(CHEMBL2152712)
Affinity DataIC50: 870nMAssay Description:Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393042(CHEMBL2152712)
Affinity DataIC50: 744nMAssay Description:Inhibition of mPGES1 in LPS-induced human whole blood assessed as suppression of PGE2 response after 20 to 24 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E synthase(Dog)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50393042(CHEMBL2152712)
Affinity DataIC50: 555nMAssay Description:Inhibition of mPGES1 in LPS-induced dog whole blood assessed as suppression of PGE2 response pre-incubated for 30 mins followed by LPS addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E synthase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393042(CHEMBL2152712)
Affinity DataIC50: 241nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)