BDBM50391643 CHEMBL2148052::CHEMBL2148053

SMILES CC(C)(C(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(Cl)c4)c(Cl)c3)c12)S(C)(=O)=O

InChI Key InChIKey=UVBKNBPCVRBUTF-UHFFFAOYSA-N

Data  39 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 50391643   

TargetDual specificity protein kinase TTK(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged TTK expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged JNK1 expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged PKCtheta expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged MEK5 expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged PLK1 expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged GSK3beta expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 after 5 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR3 after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Src after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged MEKK expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length N-terminal FLAG-tagged BMX expressed in baculovirus after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF-1R after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged IKKbeta expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged ERK1 expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length N-terminal FLAG-tagged FAK expressed in baculovirus after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged ASK1 expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged p38alpha expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of INSR after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TIE2 after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-kit after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 160nMAssay Description:Inhibition of HER4 cytoplasmic domain after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 11nMAssay Description:Inhibition of human N-terminal DYKDDDD tagged HER2 cytoplasmic domain amino acid 676 to 1255 expressed in baculovirus after 5 mins by scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 500nMAssay Description:Inhibition of N-terminal His6-tagged Aurora B expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 11nMAssay Description:Inhibition of human N-terminal DYKDDDD tagged EGFR cytoplasmic domain amino acid 669 to 1210 expressed in baculovirus after 5 mins by scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 11nMAssay Description:Inhibition of human N-terminal DYKDDDD tagged HER2 cytoplasmic domain amino acid 676 to 1255 expressed in baculovirus after 5 mins by scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 11nMAssay Description:Inhibition of human N-terminal DYKDDDD tagged EGFR cytoplasmic domain amino acid 669 to 1210 expressed in baculovirus after 5 mins by scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRalpha after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of LCK after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRbeta after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged VEGFR2 cytoplasmic domain expressed in baculovirus after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of LYN B after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of LYN A after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of c-Met after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of CSK after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 980nMAssay Description:Inhibition of N-terminal GST-tagged MEK1 after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR1 after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged TAK1 expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged B-raf expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148053 | CHEMBL2148052)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ZAP70 after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed