BDBM50390812 CHEMBL2069321

SMILES Cc1c2nnc3c(n2c(n1)c4ccccc4Cl)cc(cc3OC)OC

InChI Key InChIKey=ZXGQTWGCVTUQHJ-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50390812   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50390812(CHEMBL2069321)Copy SMILESCopy InChI

Affinity DataIC50: 0.280nMAssay Description:Inhibition of recombinant PDE10A1 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation coun...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50390812(CHEMBL2069321)Copy SMILESCopy InChI

Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant PDE2A expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation counti...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50390812(CHEMBL2069321)Copy SMILESCopy InChI

Affinity DataIC50: 0.280nMAssay Description:Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/8/2013
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL