BDBM50389047 CHEMBL2064328

SMILES Cc1cc2c(c(c1)[C@H](C)Nc3ccccc3)OC(=CC2=O)N4CCOCC4

InChI Key InChIKey=VRCXIJAYLCUSHC-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50389047   

LigandPNGBDBM50389047(CHEMBL2064328)
Affinity DataIC50: 28nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM50389047(CHEMBL2064328)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kalpha expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50389047(CHEMBL2064328)
Affinity DataIC50: 3nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM50389047(CHEMBL2064328)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminus poly-His tagged human PI3Kgamma expressed in baculovirus infected insect sf9 cells using PI(4,5)P2 as substrate preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM50389047(CHEMBL2064328)
Affinity DataIC50: 658nMAssay Description:Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM50389047(CHEMBL2064328)
Affinity DataIC50: 3nMAssay Description:Inhibition of human PI3Kbeta-mediated Akt phosphorylation at T308 residue expressed in PTEN-deficient human PC3 cells after 2 hrs by Western blot ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM50389047(CHEMBL2064328)
Affinity DataIC50: 120nMAssay Description:Inhibition of DNA-PK (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50389047(CHEMBL2064328)
Affinity DataIC50: 57nMAssay Description:Inhibition of PI3Kbeta (unknown origin) incubated for 20 mins in presence of gamma-32P-ATP by TLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50389047(CHEMBL2064328)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) incubated for 20 mins in presence of gamma-32P-ATP by TLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)