BDBM50384367 CHEMBL2031465

SMILES Cc1ccc(cc1N2C=Nc3ccc(cc3C2=O)N4CCN(CC4)C)C(=O)NC5CC5

InChI Key InChIKey=ZMAZXHICVRYLQN-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50384367   

LigandPNGBDBM50384367(CHEMBL2031465)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50384367(CHEMBL2031465)
Affinity DataIC50: 15.8nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50384367(CHEMBL2031465)
Affinity DataIC50: 27nMAssay Description:Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50384367(CHEMBL2031465)
Affinity DataIC50: 27.5nMAssay Description:Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50384367(CHEMBL2031465)
Affinity DataIC50: 16nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50384367(CHEMBL2031465)
Affinity DataIC50: 17.4nMAssay Description:Inhibition of p38alpha-mediated TNFalpha secretion in LPS-stimulated human whole blood assessed as IC50 equals to free drug concentration at human wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50384367(CHEMBL2031465)
Affinity DataIC50: 20nMAssay Description:Inhibition of p38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50384367(CHEMBL2031465)
Affinity DataIC50: 50nMAssay Description:Inhibition of p38alpha in human PBMC assessed as increase in LPS-induced ATF2 phosphorylation stimulated with LPS for 35 mins followed by compound tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)