BDBM50382686 CHEMBL2023154::US9409868, 18

SMILES c1ccc(cc1)CCNC(=O)Nc2ccc3c(c2)cn[nH]3

InChI Key InChIKey=XEZOXLSEWZHMQY-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50382686   

TargetRho-associated protein kinase 1 [1-535](Human)
H. Lee Moffin Cancer Center and Research Institute

US Patent
LigandPNGBDBM50382686(CHEMBL2023154 | US9409868, 18)
Affinity DataIC50: 650nMpH: 7.5 T: 2°CAssay Description:A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2 [1-552](Human)
H. Lee Moffin Cancer Center and Research Institute

US Patent
LigandPNGBDBM50382686(CHEMBL2023154 | US9409868, 18)
Affinity DataIC50: 670nMpH: 7.5 T: 2°CAssay Description:A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50382686(CHEMBL2023154 | US9409868, 18)
Affinity DataIC50: 650nMAssay Description:Inhibition of human His-puritin-tagged ROCK1 expressed in Sf9 cells after 1 hr by FRET-based enzyme-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50382686(CHEMBL2023154 | US9409868, 18)
Affinity DataIC50: 670nMAssay Description:Inhibition of ROCK2 after 1 hr by FRET-based enzyme-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed