BDBM50371232 CARNOSIC ACID

SMILES CC(C)c1cc2CC[C@H]3C(C)(C)CCC[C@]3(C(O)=O)c2c(O)c1O

InChI Key InChIKey=QRYRORQUOLYVBU-UHFFFAOYSA-N

Data  5 KI  7 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50371232   

TargetPancreatic triacylglycerol lipase(Human)
Sinhgad College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of pancreatic lipaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetGlutathione S-transferase omega-1(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of GSTO1-1 (unknown origin) by 4-NPG substrate based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50: 240nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP and IPP as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP and IPP as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCatenin beta-1(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to N-terminal FLAG tagged beta catenin alpha helix (H1 - 141 to 149 aa) of armadillo repeat domain (unknown origin) by STD/HSQC base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
University Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50: 2.71E+4nMAssay Description:Inhibition of bacterial NDM-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetB-cell CLL/lymphoma 9 protein(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity to N-terminal FLAG tagged beta catenin (134 to 671 residues)/FLAG tagged BCL9 domain 2 (343 to 396 residues) (unknown origin) protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetB-cell CLL/lymphoma 9 protein(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of FLAG tagged human beta-catenin/FLAG-tagged human BCL9 HD2 (343 to 396 residues) expressed in Escherichia coli BL21 protein-protein inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibition of CYP3A4 activity in human hepatocytes after 30 mins by liquid chromatography/tandem mass spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetB-cell CLL/lymphoma 9 protein(Human)
University of Southampton

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKi:  5.30E+3nMAssay Description:Competitive inhibition of wild type beta-catenin (unknown origin) expressed in Escherichia coli BL21 DE3 interaction with N-terminally biotinylated h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibition of CYP2C9 activity in human hepatocytes after 30 mins by liquid chromatography/tandem mass spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed