BDBM50370623 CHEMBL4165863::US10954217, Example 00237

SMILES O=C(OCc1ccccc1)N1CCc2ccc(cc2C1)N1CCN(CC1)C1CCCC1

InChI Key InChIKey=UQSVESYMRYILGP-UHFFFAOYSA-N

Data  20 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50370623   

TargetSigma intracellular receptor 2(Human)
University Of Texas

US Patent
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  2.70nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

TargetSigma intracellular receptor 2(Rat)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-ditolylguanidine from sigma2 receptor in rat PC12 cells by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University Of Texas

US Patent
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  51nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]-Pentazocine from sigma1 receptor in guinea pig brain membrane by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  296nMAssay Description:Displacement of [3H]-Ketanserin from human 5-HT2A receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  300nMAssay Description:Displacement of [3H]-alpha-methylhistamine from human histamine H3 receptor expressed in HEK Flp-In cells after 90 mins by microbeta scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  336nMAssay Description:Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  506nMAssay Description:Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  894nMAssay Description:Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  951nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D3 expressed in HEKT cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  1.16E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]-WAY100635 from human 5-HT1A receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  1.75E+3nMAssay Description:Displacement of [3H]-LSD from human 5-HT5A receptor expressed in Flp-In CHO cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  1.76E+3nMAssay Description:Displacement of [125I]-iodoaminopotentidine from human histamine H2 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  1.77E+3nMAssay Description:Displacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  2.29E+3nMAssay Description:Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  2.47E+3nMAssay Description:Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M5 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  2.68E+3nMAssay Description:Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M4 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  3.49E+3nMAssay Description:Displacement of [3H]-Prazosin from human adrenergic alpha1A receptor after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370623(CHEMBL4165863 | US10954217, Example 00237)
Affinity DataKi:  7.33E+3nMAssay Description:Displacement of [3H]-Prazosin from human adrenergic alpha1B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed