BDBM50368452 CHEMBL4168305

SMILES CC(C)c1ccc(cc1C#Cc2cnc3n2ccnc3)C(=O)Nc4cc(cc(c4)C(F)(F)F)CN5CCN(CC5)C

InChI Key InChIKey=IUGBGEUCXVKGQK-UHFFFAOYSA-N

Data  5 IC50  12 Kd

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50368452   

TargetEphrin type-A receptor 7(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  200nMAssay Description:Binding affinity to human EPHA7More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  11nMAssay Description:Binding affinity to human TrkBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataIC50: 40nMAssay Description:Inhibition of TrkB (unknown origin) by TR-FRET based LANCE ULTRA kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNT-3 growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataIC50: 18nMAssay Description:Inhibition of TrkC (unknown origin) by TR-FRET based LANCE ULTRA kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  100nMAssay Description:Binding affinity to human TrkAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 10(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  10nMAssay Description:Binding affinity to human LOKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  260nMAssay Description:Binding affinity to human EPHB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetEphrin type-A receptor 8(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  79nMAssay Description:Binding affinity to human EPHA8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  370nMAssay Description:Binding affinity to human TIE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  8nMAssay Description:Binding affinity to human DDR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  7.90nMAssay Description:Binding affinity to human DDR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ABL1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataIC50: 494nMAssay Description:Inhibition of Abl1 (unknown origin) incubated for 1 hr in presence of Tyrosine-2 peptide substrate by FRET based Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  9.30nMAssay Description:Binding affinity to human TrkCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  180nMAssay Description:Binding affinity to human LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataKd:  260nMAssay Description:Binding affinity to human EPHA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50368452(CHEMBL4168305)
Affinity DataIC50: 20nMAssay Description:Inhibition of DDR2 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed