BDBM50366992 CHEMBL4168754

SMILES c1ccc(cc1)[C@H]([C@@H]2[C@H]([C@H]([C@@H](O2)n3ccc4c3ncnc4N)O)O)O

InChI Key InChIKey=WWOOWAHTEXIWBO-UHFFFAOYSA-N

Data  4 IC50  1 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50366992   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366992(CHEMBL4168754)
Affinity DataKd:  6nMAssay Description:Inhibition of PRMT5/MEP50 complex (unknown origin) expressed in Sf9 insect cells using SGRGKGGKGLGKGGAKRHRKVLRDK-Biotin as substrate by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 5(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366992(CHEMBL4168754)
Affinity DataIC50: 25nMAssay Description:Inhibition of PRMT5 in human MCF7 cells assessed as reduction in SmBB'-Rme2s levels after 48 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366992(CHEMBL4168754)
Affinity DataIC50: 22nMAssay Description:Inhibition of PRMT5/MEP50 complex (unknown origin) expressed in Sf9 insect cells using SGRGKGGKGLGKGGAKRHRKVLRDK-Biotin as substrate measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 5(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366992(CHEMBL4168754)
Affinity DataEC50:  40nMAssay Description:Inhibition of PRMT5 in human MCF7 cells assessed as skipping of Mdm4 exon 6 mRNA splicing after 72 hrs by qRT-PCR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366992(CHEMBL4168754)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (1 to 637 residue) /full length human N-terminal His tagged MEP50 expressed in baculovir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 5(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366992(CHEMBL4168754)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)