BDBM50365463 CHEMBL1232461

SMILES CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc12

InChI Key InChIKey=AAAQFGUYHFJNHI-UHFFFAOYSA-N

Data  20 KI  689 IC50  211 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 921 hits for monomerid = 50365463   

TargetH/ACA ribonucleoprotein complex subunit DKC1(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  6nMAssay Description:Binding affinity against DKC1 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetH/ACA ribonucleoprotein complex non-core subunit NAF1(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  8nMAssay Description:Binding affinity against NAF1 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetArginine/serine-rich protein PNISR(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  8nMAssay Description:Binding affinity against SFRS18 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  9nMAssay Description:Binding affinity against HSP90AA1 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPinin(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of PNN (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPeptidyl-prolyl cis-trans isomerase G(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of PPIG (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHepatoma-derived growth factor-related protein 3(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDGF2 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetG patch domain-containing protein 8(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of GPATCH8 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRNA-binding protein 39(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  10nMAssay Description:Binding affinity against RBM39 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetH/ACA ribonucleoprotein complex subunit DKC1(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of DKC1 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLupus La protein(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of SSB (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTreacle protein(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of TCOF1 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNucleophosmin(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of NPM1 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPeptidyl-prolyl cis-trans isomerase G(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  11nMAssay Description:Binding affinity against PPIG (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetG patch domain-containing protein 8(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  12nMAssay Description:Binding affinity against GPATCH8 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAF4/FMR2 family member 1(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  13nMAssay Description:Binding affinity against AFF1 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein SON(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  14nMAssay Description:Binding affinity against SON (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRNA-binding protein 25(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  14nMAssay Description:Binding affinity against RBM25 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetChromatin-remodeling ATPase INO80(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  15nMAssay Description:Binding affinity against INO80 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPinin(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  15nMAssay Description:Binding affinity against PNN (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHepatoma-derived growth factor-related protein 3(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  15nMAssay Description:Binding affinity against HDGF2 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPre-mRNA-splicing factor CWC22 homolog(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  15nMAssay Description:Binding affinity against CWC22 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHemoglobin subunit beta(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 16nMAssay Description:Inhibition of HBB (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetChromodomain-helicase-DNA-binding protein 9(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  16nMAssay Description:Binding affinity against CHD9 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPre-mRNA-processing factor 40 homolog A(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  16nMAssay Description:Binding affinity against PRPF40A (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclin-L2(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  16nMAssay Description:Binding affinity against CCNL2 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTreacle protein(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  18nMAssay Description:Binding affinity against TCOF1 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  19nMAssay Description:Binding affinity to human partial length BRD4-BD2 (K333 to E460 residues) expressed in bacterial expression system by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  19nMAssay Description:Binding affinity against HSP90AB1 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProliferating cell nuclear antigen(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  19nMAssay Description:Binding affinity against PCNA (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetATPase family AAA domain-containing protein 5(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  19nMAssay Description:Binding affinity against ATAD5 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetH/ACA ribonucleoprotein complex non-core subunit NAF1(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 20nMAssay Description:Inhibition of NAF1 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetChromodomain-helicase-DNA-binding protein 8(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  20nMAssay Description:Binding affinity against CHD8 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRNA-binding protein 25(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 20nMAssay Description:Inhibition of RBM25 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 20nMAssay Description:Inhibition of N-terminal His-tagged BRD4 (BD2) (unknown origin) using biotinylated tetra-acetylated histone H4 peptide after 30 mins by alpha-screen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetApoptotic chromatin condensation inducer in the nucleus(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 20nMAssay Description:Inhibition of ACIN1 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 20nMAssay Description:Inhibition of HSP90AA1 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetChromatin-remodeling ATPase INO80(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 20nMAssay Description:Inhibition of INO80 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 20nMAssay Description:Inhibition of SMARCA2 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBromodomain-containing protein 9(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  20nMAssay Description:Binding affinity against BRD9 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAF4/FMR2 family member 1(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 20nMAssay Description:Inhibition of AFF1 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPre-mRNA-splicing factor CWC22 homolog(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 20nMAssay Description:Inhibition of CWC22 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/arginine repetitive matrix protein 2(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 20nMAssay Description:Inhibition of SRRM2 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 11B(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 20nMAssay Description:Inhibition of CDC2L1 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRNA polymerase-associated protein RTF1 homolog(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  21nMAssay Description:Binding affinity against RTF1 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTranscription activator BRG1(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  21nMAssay Description:Binding affinity against SMARCA4 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRNA polymerase-associated protein CTR9 homolog(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  22nMAssay Description:Binding affinity against CTR9 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  22nMAssay Description:Binding affinity to human partial length BRD3-BD1 (P24 to E144 residues) expressed in bacterial expression system by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSerine/arginine repetitive matrix protein 2(Homo sapiens)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKd:  23nMAssay Description:Binding affinity against SRRM2 (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataKi:  23nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant human N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) expressed in Rosetta2 D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
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