BDBM50364378 CHEMBL1950289

SMILES c1c(cc(c(c1F)Nc2nc3cnc(nc3n2[C@H]4CCOC4)NC5CCC(CC5)O)F)F

InChI Key InChIKey=IBGLGMOPHJQDJB-UHFFFAOYSA-N

Data  2 KI  19 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50364378   

TargetMitogen-activated protein kinase 3(Human)
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 480nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 6nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 7nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 61nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 8(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of c-Jun phosphorylation in LPS-stimulated JNK2-/- mouse embryonic fibroblast incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 8(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of c-Jun phosphorylation in LPS-stimulated JNK1-/- mouse embryonic fibroblast incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 5nMAssay Description:Inhibition of JNK2 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 133nMAssay Description:Inhibition of JNK1 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 8(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of JNK1 in mouse RAW264.7 cells assessed as inhibition of c-Jun phosphorylation incubated for 30 mins by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 10(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 6nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 61nMAssay Description:Inhibition of hexa-His-tagged JNK1 expressed in baculoviral system using GST-tagged c-Jun as substrate preincubated for 15 mins prior ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 7nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 61nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 380nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 480nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of p38alpha using myelin basic protein as substrate preincubated for 15 mins prior ATP addition measured after 60 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 6nMAssay Description:Inhibition of hexa-His-tagged JNK3 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataIC50: 7nMAssay Description:Inhibition of hexa-His-tagged JNK2 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataKi:  6.20nMAssay Description:Inhibition of hexa-His-tagged JNK2 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50364378(CHEMBL1950289)
Affinity DataKi:  44nMAssay Description:Inhibition of hexa-His-tagged JNK1 expressed in baculoviral system using GST-tagged c-Jun as substrate preincubated for 15 mins prior ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)