BDBM50364141 CHEMBL1951415

SMILES Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1

InChI Key InChIKey=WUDBUIUHVNECTM-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50364141   

TargetCasein kinase I isoform epsilon(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 80nMAssay Description:Inhibition of Casein kinase 1 epsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 8nMAssay Description:Inhibition of CK1epsilon (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 14nMAssay Description:Inhibition of CK1delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 14nMAssay Description:Inhibition of full-length human CK1delta expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL competent cells using PLSRTLpSVASLPGL as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of full-length human CK1epsilon expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL competent cells using PLSRTLpSVASLPGL as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCasein kinase 1, delta tv1(Pig)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of porcine brain CK-1delta using RRKHAAIGpSAYSITA peptide as substrate incubated for 30 mins in presence of [gamma-33P]-ATP by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 13nMAssay Description:Inhibition of human CK1delta in presence of [gamma33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 80nMAssay Description:Inhibition of human CK1epsilon in presence of [gamma33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 32nMAssay Description:Inhibition of human full length CK1delta1 (2 to 415 residues) using PLSRTLpSVASLPGL as substrate after 2 hrs by kinase-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 32nMAssay Description:Inhibition of human full length polyhistidine-tagged CK1epsilon expressed in Escherichia coli BL21-Codon-Plus (DE3)-RIL using PLSRTLpSVASLPGL as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 81nMAssay Description:Inhibition of human CK1 delta transfected in african green monkey cos7 cells after overnight incubation by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 13nMAssay Description:Inhibition of Casein kinase 1 deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 130nMAssay Description:Inhibition of CK1epsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 80nMAssay Description:Inhibition of CK1deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 190nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 150nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant CK1delta expressed in Escherichia coli using PLSRTLpSVASLPGL as substrate after 2 hrs by KinaseGlo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 8nMAssay Description:Inhibition of human CK1epsilon expressed in Escherichia coli BL21 using PLSRTLpSVASLPGL as substrate after 3 hrs by KinaseGlo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of CK1 delta (unknown origin) using PLSRTLpSVASLPGL as substrate after 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50: 29nMAssay Description:Inhibition of CK1 epsilon (unknown origin) using PLSRTLpSVASLPGL as substrate after 85 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed