BDBM50359366 CHEMBL1929387::CHEMBL1929396::US20240115577, Compound 12

SMILES Cc1cc2ncc(cn2n1)C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N

InChI Key InChIKey=LDXYBEHACFJIEL-UHFFFAOYSA-N

Data  13 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50359366   

TargetProlyl endopeptidase FAP(Human)
Sanwa Kagaku Kenkyusho

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 7.27E+4nMAssay Description:Inhibition of human recombinant FAP expressed in baculovirus-infected Sf9 insect cells using H-Ala-Pro-AFC as substrate after 60 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Sanwa Kagaku Kenkyusho

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human recombinant DPP-4 using H-Gly-Pro-AMC as substrate preincubated for 30 mins before substrate addition measured after 20 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 8(Human)
Sanwa Kagaku Kenkyusho

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 68nMAssay Description:Inhibition of human recombinant DPP-8 expressed in Sf9 cells using H-Gly-Pro-AMC as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Sanwa Kagaku Kenkyusho

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant DPP-9 expressed in Sf9 cells using H-Gly-Pro-AMC as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Sanwa Kagaku Kenkyusho

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 1.77E+5nMAssay Description:Inhibition of DPP-2 expressed in human Caco-2 cells using H-Lys-Ala-AMC as substrate preincubated for 30 mins before substrate addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanwa Kagaku Kenkyusho

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sanwa Kagaku Kenkyusho

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sanwa Kagaku Kenkyusho

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Sanwa Kagaku Kenkyusho

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sanwa Kagaku Kenkyusho

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sanwa Kagaku Kenkyusho

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Sanwa Kagaku Kenkyusho

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human DPP4 expressed in Silkworm baculovirus system preincubated for 30 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 4(Human)
Sanwa Kagaku Kenkyusho

Curated by ChEMBL
LigandPNGBDBM50359366(CHEMBL1929387 | CHEMBL1929396 | US20240115577, Com...)
Affinity DataIC50: 11.4nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)