BDBM50350236 CHEMBL1812335

SMILES c1ccc2c(c1)CN(C2)C(=O)[C@@H](Cc3ccc(cc3Cl)Cl)N

InChI Key InChIKey=JFWNERIMAUEHNN-UHFFFAOYSA-N

Data  14 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50350236   

TargetHistone deacetylase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350236(CHEMBL1812335)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human HDAC1 using rhodamine as substrate after 1 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350236(CHEMBL1812335)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human HDAC2 using rhodamine as substrate after 1 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350236(CHEMBL1812335)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human HDAC6 using rhodamine as substrate after 1 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350236(CHEMBL1812335)
Affinity DataIC50: 90nMAssay Description:Inhibition of N terminal hexahistidine-tagged human HDAC8 expressed in Sf9 cells after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350236(CHEMBL1812335)
Affinity DataIC50: 2.74E+4nMAssay Description:Inhibition of human KDAC1 using substrate A after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50350236(CHEMBL1812335)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human KDAC3 using FITC-labeled p53 acetylated peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350236(CHEMBL1812335)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human KDAC6 using FITC-labeled histone H4 acetylated peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350236(CHEMBL1812335)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of human KDAC8 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 8(Blood fluke)
Washington University

Curated by ChEMBL
LigandPNGBDBM50350236(CHEMBL1812335)
Affinity DataIC50: 2.91E+4nMAssay Description:Inhibition of Schistosoma mansoni KDAC8 using (FAM)-labeled peptide as substrate after 60 mins by microfluidic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2019
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350236(CHEMBL1812335)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human recombinant HDAC 2 by HDAC-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350236(CHEMBL1812335)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant HDAC 1 by HDAC-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350236(CHEMBL1812335)
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant HDAC 8 by HDAC-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350236(CHEMBL1812335)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant HDAC 6 by HDAC-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350236(CHEMBL1812335)
Affinity DataIC50: 210nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)