BDBM50346918 CHEMBL1738710

SMILES Cc1ccc(cc1N2C=NC(=C(C2=O)Cl)OCc3ccc(cc3F)F)C(=O)NCCO

InChI Key InChIKey=XIPYKUQAZQIESI-UHFFFAOYSA-N

Data  1 KI  33 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50346918   

TargetTyrosine-protein kinase SYK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MKK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MST2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MKK7More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MYT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 249nMAssay Description:Inhibition of p38beta kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 17nMAssay Description:Inhibition of p38alpha kinase in human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ROCK IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 12nMAssay Description:Inhibition of p38alpha kinase-dependent HSP-27 phosphorylation in human U937 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MKK6More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AURKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TBK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346918(CHEMBL1738710)
Affinity DataKi:  193nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)