BDBM50345259 CHEMBL1782530::cis-7-(4-aminocyclohexylamino)-5-bromobenzofuran-2-carboxylic acid

SMILES N[C@H]1CC[C@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O

InChI Key InChIKey=BLBAWGODFTZAEY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50345259   

TargetSerine/threonine-protein kinase pim-1(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(cis-7-(4-aminocyclohexylamino)-5-bromobenzofuran-2...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(cis-7-(4-aminocyclohexylamino)-5-bromobenzofuran-2...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(cis-7-(4-aminocyclohexylamino)-5-bromobenzofuran-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(cis-7-(4-aminocyclohexylamino)-5-bromobenzofuran-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(cis-7-(4-aminocyclohexylamino)-5-bromobenzofuran-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(cis-7-(4-aminocyclohexylamino)-5-bromobenzofuran-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(cis-7-(4-aminocyclohexylamino)-5-bromobenzofuran-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(cis-7-(4-aminocyclohexylamino)-5-bromobenzofuran-2...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant PIM1 in presence of ATP by ELISA based spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2020
Entry Details Article
PubMed