BDBM50343442 CHEMBL1775179::isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate

SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O

InChI Key InChIKey=XTRUQJBVQBUKSQ-UHFFFAOYSA-N

Data  1 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50343442   

TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50343442(isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)...)
Affinity DataEC50:  2.70nMAssay Description:Agonist activity at human GPR119 by melanophore assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50343442(isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50343442(isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)...)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human GPR119 expressed in human HEK293 cells assessed as increase in adenylate cyclase activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Rat)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50343442(isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at rat GPR119 by melanophore assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50343442(isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)...)
Affinity DataKi:  100nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed