BDBM50342890 6-(benzo[d][1,3]dioxol-5-yl)-N-(cyclopentylmethyl)quinazolin-4-amine::CHEMBL1354134

SMILES C(Nc1ncnc2ccc(cc12)-c1ccc2OCOc2c1)C1CCCC1

InChI Key InChIKey=HOLVNBCAYHKGJL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50342890   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342890BDBM50342890(6-(benzo[d][1,3]dioxol-5-yl)-N-(cyclopentylmethyl)...)
Affinity DataIC50: 76nMAssay Description:Inhibition of Dyrk1A kinase using ATP as substrate by 33P radiolabeled kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK4(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342890BDBM50342890(6-(benzo[d][1,3]dioxol-5-yl)-N-(cyclopentylmethyl)...)
Affinity DataIC50: 90nMAssay Description:Inhibition of Clk4 kinase using ATP as substrate by 33P radiolabeled kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342890BDBM50342890(6-(benzo[d][1,3]dioxol-5-yl)-N-(cyclopentylmethyl)...)
Affinity DataIC50: 227nMAssay Description:Inhibition of Clk1 kinase using ATP as substrate by 33P radiolabeled kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342890BDBM50342890(6-(benzo[d][1,3]dioxol-5-yl)-N-(cyclopentylmethyl)...)
Affinity DataIC50: 313nMAssay Description:Inhibition of Dyrk1B kinase using ATP as substrate by 33P radiolabeled kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342890BDBM50342890(6-(benzo[d][1,3]dioxol-5-yl)-N-(cyclopentylmethyl)...)
Affinity DataIC50: 486nMAssay Description:Inhibition of Clk2 kinase using ATP as substrate by 33P radiolabeled kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK3(Human)
National Human Genome Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342890BDBM50342890(6-(benzo[d][1,3]dioxol-5-yl)-N-(cyclopentylmethyl)...)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of Clk3 kinase using ATP as substrate by 33P radiolabeled kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed