BDBM50340758 (S)-6-(4-fluorobenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)-N-hydroxyhexanamide::CHEMBL1760318

SMILES CO[C@H](C[C@H](CCCCNCc1ccc(cc1)F)C(=O)NO)c2ccc(cc2)F

InChI Key InChIKey=SZPWYHRMRFNOHH-UHFFFAOYSA-N

Data  7 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50340758   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340758((S)-6-(4-fluorobenzylamino)-2-((R)-2-(4-fluorophen...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340758((S)-6-(4-fluorobenzylamino)-2-((R)-2-(4-fluorophen...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340758((S)-6-(4-fluorobenzylamino)-2-((R)-2-(4-fluorophen...)
Affinity DataKi:  0.580nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340758((S)-6-(4-fluorobenzylamino)-2-((R)-2-(4-fluorophen...)
Affinity DataKi:  0.580nMAssay Description:Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage metalloelastase(Human)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340758((S)-6-(4-fluorobenzylamino)-2-((R)-2-(4-fluorophen...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of MMP-12 using OmniMMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340758((S)-6-(4-fluorobenzylamino)-2-((R)-2-(4-fluorophen...)
Affinity DataKi:  2.10E+4nMAssay Description:Inhibition of MMP-9 using OmniMMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340758((S)-6-(4-fluorobenzylamino)-2-((R)-2-(4-fluorophen...)
Affinity DataKi:  3.30E+4nMAssay Description:Inhibition of MMP-1 using OmniMMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340758((S)-6-(4-fluorobenzylamino)-2-((R)-2-(4-fluorophen...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of MMP-3 using OmniMMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340758((S)-6-(4-fluorobenzylamino)-2-((R)-2-(4-fluorophen...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of MMP-14 using OmniMMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed