BDBM50339997 (R)-2-(3-amino-1-phenylpropoxy)-4-chlorobenzonitrile oxalate::CHEMBL1762473

SMILES c1ccc(cc1)[C@@H](CCN)Oc2cc(ccc2C#N)Cl

InChI Key InChIKey=GPCXUXJZOSOVLY-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50339997   

TargetSodium-dependent noradrenaline transporter(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50339997((R)-2-(3-amino-1-phenylpropoxy)-4-chlorobenzonitri...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50339997((R)-2-(3-amino-1-phenylpropoxy)-4-chlorobenzonitri...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50339997((R)-2-(3-amino-1-phenylpropoxy)-4-chlorobenzonitri...)
Affinity DataIC50: 400nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50339997((R)-2-(3-amino-1-phenylpropoxy)-4-chlorobenzonitri...)
Affinity DataIC50: 900nMAssay Description:Inhibition of iNOS in intact human DLD1 cells assessed as nitric oxide productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Human)
Astrazeneca Charnwood

Curated by ChEMBL
LigandPNGBDBM50339997((R)-2-(3-amino-1-phenylpropoxy)-4-chlorobenzonitri...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)