BDBM50339006 6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine::6-(2-aminopyrimidin-4-yl)-1H-indazol-3-amine::CHEMBL1688215

SMILES Nc1n[nH]c2cc(ccc12)-c1ccnc(N)n1

InChI Key InChIKey=QVWIVWPIJUYRRF-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50339006   

LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 5.69E+3nMAssay Description:Inhibition of ASK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 990nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 840nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAurora kinase A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 390nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 280nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 370nMAssay Description:Inhibition of His-tagged-truncated human PDK1 preincubated with substrate biotinylated-AKT3 for 30 mins measured after 3 hrs by Scintillation proximi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SGK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 6.34E+3nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetInsulin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of INSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 100nMAssay Description:Inhibition of IKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAurora kinase B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAurora kinase A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 398nMAssay Description:Inhibition of aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
LigandPNGBDBM50339006(6-(2-Amino-4-pyrimidinyl)-1H-indazol-3-amine | 6-(...)
Affinity DataIC50: 398nMAssay Description:Inhibition of PDK1-mediated AKT phosphorylation at Thr308 residue in human PC3 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed