BDBM50336457 (3S,5Z,8S,9R,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione::CHEMBL1077979::CHEMBL1668411::CHEMBL1801950

SMILES COc1cc(O)c2c(CCCC(=O)C(=O)C(=O)CCC[C@H](C)OC2=O)c1

InChI Key InChIKey=AYXFORKQNMKTGL-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50336457   

TargetGlycogen synthase kinase-3 alpha(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human recombinant GSK3alpha in cell free system after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of MKK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 80nMAssay Description:Inhibition of Erk2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 6nMAssay Description:Inhibition of MEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 300nMAssay Description:Inhibition of MEK7More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTranscription factor p65(Human)
University of North Carolina At Greensboro

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of NFkappa p65 isolated from nuclear extract of human HeLa cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTranscription factor p65(Human)
University of North Carolina At Greensboro

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 250nMAssay Description:Inhibition of NFkappa p65 isolated from nuclear extract of human HeLa cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant MEK1 expressed in insect cells after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human recombinant VEGFR2 expressed in Sf9 cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human recombinant GSK3-beta in cell free system after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant VEGFR3 in cell free system after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of human recombinant PDGFRalpha in cell free system after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of human recombinant c-kit kinase in cell free system after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Covalution Pharma

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human recombinant ERK2 expressed in E.coli after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant PDGFRbeta expressed in insect cells after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant ERK5 in cell free system after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant VEGFR1 expressed in Sf9 cells after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant ERK1 expressed in E.coli after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
National University of Ireland

Curated by ChEMBL
LigandPNGBDBM50336457(CHEMBL1668411 | CHEMBL1077979 | CHEMBL1801950 | (3...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human recombinant FLT-3 kinase expressed in insect cells after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed