BDBM50335374 (3S,9S)-9,16-dihydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-hexahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione::CHEMBL1651521::CHEMBL1651522

SMILES COc1cc(O)c2c(CCC[C@H](O)CC(=O)C=CC[C@H](C)OC2=O)c1

InChI Key InChIKey=QMEZKJBCLUGJTN-UHFFFAOYSA-N

Data  38 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50335374   

LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1R by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Axl by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2A by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ZAP70 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetEphrin type-A receptor 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EPHA4 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR3 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3-beta by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HGFR by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetAurora kinase A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora A kinase by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK1 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDK1 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKAalpha by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKN1 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKN2 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38alpha by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of RET by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LCK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TYK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of cKIT by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetInsulin receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of INSR by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ROCK2 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ALK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 763nMAssay Description:Inhibition of ALK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of EPHB4 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of ERK2 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 190nMAssay Description:Inhibition of VEGFR2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 673nMAssay Description:Inhibition of cKIT by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of LCK by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 150nMAssay Description:Inhibition of MNK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of TYK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of VEGFR2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ERK2 by Caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EPHB4 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RET by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed