BDBM50330062 1-(3-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine::CHEMBL1271705

SMILES CCCCc1nc2c(n1Cc3cccc(c3)CN)c4ccccc4nc2N

InChI Key InChIKey=AKLBWCHTGHQPMA-UHFFFAOYSA-N

Data  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50330062   

TargetToll-like receptor 8(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50330062(1-(3-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50330062(1-(3-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human TLR7 expressed in HEK-Blue-7 cells assessed as increase in NF-kappaB activation by sAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50330062(1-(3-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human TLR7 expressed in HEK293 cells assessed as activation of NFkappaB incubated for 18 to 24 hrs by SEAP reporter gene based as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50330062(1-(3-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as activation of NFkappaB incubated for 18 to 24 hrs by SEAP reporter gene based as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)