BDBM50326992 CHEMBL471737::ivabradine

SMILES CN(CCCN1CCc2cc(c(cc2CC1=O)OC)OC)C[C@H]3Cc4c3cc(c(c4)OC)OC

InChI Key InChIKey=ACRHBAYQBXXRTO-UHFFFAOYSA-N

Data  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50326992   

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Mouse)
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (Heterobiolab)

Curated by ChEMBL
LigandPNGBDBM50326992(ivabradine | CHEMBL471737)
Affinity DataEC50:  4.50E+3nMAssay Description:Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Mouse)
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (Heterobiolab)

Curated by ChEMBL
LigandPNGBDBM50326992(ivabradine | CHEMBL471737)
Affinity DataEC50:  4.52E+3nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4(Human)
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (Heterobiolab)

Curated by ChEMBL
LigandPNGBDBM50326992(ivabradine | CHEMBL471737)
Affinity DataEC50:  4.28E+3nMAssay Description:Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)